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Yes, cactus quills need to be removed if they're barbed. The longer, sharper quills take longer to be dissolved by the body chemistry. So they're best removed as quickly after the embedding as possible. Modified cactus leaves in the form of fine hairs and bristles don't take as long to dissolve. But their presence still may be an irritant. So prompt removal may be on the better side of valor.

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Q: Do cactus quills need to be removed?
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