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Do neural tube holes close up with maturation?

Updated: 9/17/2019
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Q: Do neural tube holes close up with maturation?
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What week of gestation does the neural tube close?

The neural tube closes around the 28th day of gestation, so that would be at the end of the fourth week.


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In the embryo the neural tube forms the central nervous system in the fetus, which is the brain and spinal cord. The reason pregnant women are given folic acid supplementation is to help prevent neural tube defects, which can range from fairly benign all the way to anencephaly (where the baby is born without a brain).


In a toad embryo the neural tube does what?

The neural tube is the embryonic predecessor of the brain and spinal cord. Which means, most of what it "does" is develop into a brain and spinal cord. The neural tube is initially formed almost exclusively of stem and progenitor cells. Over time, these stem and progenitor cells adopt specific identities and begin to differentiate neurons and later glial cells and these cells begin forming neural circuits. By the time the neural tube has developed to a point where it is capable of carrying out rudimentary neurological functions, the nomenclature is generally changed to brain and spinal cord rather than neural tube.


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