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Sam breaks up with Quinn because in the previous episode "Silly love songs" Quinn makes out with Finn and they both come down with a case of Mono. Santana was the one who gave Finn Mono when he was trying to raise money and get a kiss from Quinn by setting up a kissing booth. In the episode "Comeback" Santana and Sam start to go out.

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13y ago
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12y ago

yes, later in the season they do break up, however Sam sings a Justin Bieber song to get Quinn back.

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12y ago

No, Quinn went back to Finn and Sam started dating Mercedes.

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9y ago

Yes. They break up in "Born This Way" Season 2, Episode 18.

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13y ago

they were until the end of episode "comeback"

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Q: Do Sam and Santana break up in glee?
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