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It depends entirely on the individual. Fentanyl stays in the system for a lot longer than acute meds do, so you've got several hours to either put a new patch on or swap the old one. Ideally, you want to put a new patch on a couple of hours before the old one is supposed to expire, but it's important to note that the normally prescribed 72 hour mark doesn't apply to everyone, and isn't fixed in stone, something that a lot of pain doctors have trouble understanding.

Fentanyl transdermal patches regulate the dosage by body heat - this means if you're engaged in physical activity or anything else that raises your body temp, the dosage delivery is increased, and the expiration time is decreased. Also, a small percentage of the population (myself included) require a 48 hour change rather than 72. It's more typical of high-dose opiate patients like myself.

The problem lies in that for many years, Janssen Pharmaceuticals' literature on Duragesic had 72 hours as the effective dosage period. However, they knew that some people didn't get that much. Though they finally changed the literature about 4 years ago to say that 48-72 hours, a lot of doctors don't keep up with those kinds of minor changes, and a lot of pain patients don't understand the proper way to communicate with their pain doctors. The real problem is that if you're getting patches based on a 72 hour dosage rate, and you're falling shorter, you'll wind up having less patches for your monthly prescription. In those cases, keeping an accurate Pain Diary is essential in showing your doctor that his prescription isn't right for your particular case and needs to be adjusted. If you're a fairly new Pain Management patient, or have an idiot for a pain doctor, it can be frustrating.

Where you place the patch is important as well. I've always used my biceps in the 10 years I've been using them, since it's easy to add them and the skin doesn't flex as much as it does in other areas. Even during the times when I've had to increase to 200mcg (2x100mcg patches), I still use both arms, taking on patch off for a few hours to let the skin breathe, clean it, then put a new one on, and then do the same with the other one.

As I said, if you overlap the patches (put a new one on in a new location as the other one is about to expire) you'll have no withdrawals to deal with. It takes a couple of hours for the new patch to ramp up to full delivery, so as the old one is getting weaker the new one is slowly catching up. The result helps to keep your overall maintenance dose fairly steady.

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13y ago
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11y ago

For most patients, but not all; there is a small percentage who only get about 48 hours.

Also, if your patch dose is too low, you'll start feeling withdrawal symptoms and pain a lot sooner than 72 hours.

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11y ago

If you're leaving your old patch on you're just wasting your time and skin. If it 's empty, it's empty.

There is a small percentage of patients (about 10-15%) that only get 48hrs of pain relief from fentanyl patches, so if you're one of those (like me) then you're not alone. If you've got a Doctor Who doesn't believe that, find another one. They changed the drug literature years ago to note just that possibility. It also depends on your activity level - if it's higher, your dosage rate increases.

The other thing is that you might not have good patch adhesion, or it might be in a bad spot. Remember that they must always be ABOVE THE WAIST. Keeping them on can be a pain, but read my answer on how to keep them on with good adhesion - link is below.

You might also have just become more tolerant to 50mcg patches and need to move up to 75's. That's not an unusual occurrence for patch users.

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11y ago

No - they're only 72 hours. However, there is a small percentage of patients who are recognized (myself included) to only get 48hrs of of relief from patches. In such cases, you need to work with your doctor to double your monthly patch allowance to compensate.

If you doctor doesn't believe it, then show him/her the literature on the patches - I've added a link to Duragesic's dosage information below.

If he still doesn't do it, find another doctor.

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10y ago

You can take the Fentanyl patch off after 2 days, but you will no longer get pain relief. If you have been using the patch for some time, do not stop abruptly.

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11y ago

yes

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Q: Does Fentanyl last 72 hours
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How long does liquid Fentanyl stay in your system?

72 hours for any pill or liquid drug


How long before Fentanyl can no longer be detected in basic blood work or a urine test?

In a study of 7 patients given fentanyl in surgery - Fentanyl and its two metabolites (norfentanyl and despropionylfentanyl) were extracted from samples and analyzed by gas chromatography/mass spectrometry. Unchanged fentanyl was detectable in urine in all patients immediately postoperatively and in 3 of 7 patients at 24 hours. By 72 hours, fentanyl was undetectable. Norfentanyl was present in larger quantities than fentanyl immediately postoperatively and was detected in all patients at 48 hours and in 4 of 7 patients at 96 hours.


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Everyone is different, but I was clear after 72-84 hours.


What is the difference between Fentanyl and oxycodone?

Fentanyl is normally primarily used as a general anesthetic, where Oxycodone is an acute pain medication. However, when prescribed as a chronic pain med, Fentanyl Transdermal Patches are typically the opiate therapy of last resort for severe chronic pain patients, who have used all other lesser forms of opiates without long term success, their opiate tolerance has exceeded acute pain med limits, or their pain requires 24/7 relief. Most acute meds like Oxycodone only last 4-6 hours; the longest lasting timed-release version of Oxycodone (OxyContin) at best last 12 hours. Fentanyl patches last anywhere from 48-72 hours depending on the patient and their opiate tolerance level.The biggest difference of course is strength; Fentanyl is the strongest opiate on the planet, and is 100x stronger than morphine.


What is he onset of action of Fentanyl patch?

On first application it usually takes 24-72 hours for serum concentrations of fentanyl to reach a peak, so it may not be until the second patch has been applied that a steady-state concentration is reached. Break-through analgesia may be required initially. Wean other analgesics slowly after the first patch.2 The patch should be changed every 72 hours.


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How long do Fentanyl patches stay in your system?

The amount of time it takes for the amount of drug in the body to reduce by 50% is called the half-life. It takes approximately five to six half lives for the drug to be cleared from the body. The half-life for fentanyl patches is 9.5 to 12.4 hours. Multiply that by 6 and it could take up to 74.4 hours to clear the drug. You can do the math. Fentanyl lozenges-approx. 7 hours. Duragesic takes a few hours to kick in and is supposed to last up to 72 hours (like how Oxycontin is supposed to last 12 hours) but most people find it lasts 36-60 hours. From my experience I've found fentanyl patches to last about 48-54 hours. In regards to drug testing, assuming it's a UA, fentanyl takes longer to clear than most opiates, it would take AT LEAST 48 hours after the removal of the patch (assuming you wore it for at least 2 days)