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Yes, the MHC may interfere with transfusion even though the blood groups of the donor and the recipient are the same. Blood contains white and red blood cells. Blood grouping is for red blood cell antigens. White cells carry the MHC antigens. White blood cells are usually few in number in donated blood, so they are not a major concern. However, the patient may react to MHC antigens present in the transfused white blood. This is more common in patients who have received many transfusions before, since they are sensitized to white cell antigens (MHC).

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Q: Does MHC interfere blood transfusioneven though the same blood group?
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