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If you mean a Microsoft operating system, such as XP or Vista or Windows 7, then on an IBM PC, it does need to be running before Excel can run. You can also get Excel for other types of computers that do not use a Windows operating system, such as an Apple computer, and Excel can run on those. So it depends on the type of computer and the version of Excel.

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Q: Does Microsoft have to be running for Excel to work?
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