Does a 2003 Ford F-250 have spark plugs?

That depends if you have a gasoline engine

On a 2003 Ford F-250 if you have the 5.4 liter gasoline V8 engine it has ( 8 spark plugs )

If you have the 6.8 liter gasoline V10 engine it has ( 10 spark plugs )

If you have the 7.3 liter DIESEL engine it doesn't have any spark plugs