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No but I honestly would not recommend this crossing of breeds as the heavier dog the Dane is crossed with the more pressure it puts on the heart, Danes have very small hearts compared to their size in pure breed Danes..... plus the lower eye lid will sag and cause problems in the dogs eyes. If you want a large dog go for an Neapolitan Mastiff

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Q: Does any one know where an English Mastiff mixed with a Great Dane breeder is?
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