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It messes up your sinuss (making your nose constantly run), it makes your heart race faster, and it messes up your body. Just say NO to ALL DRUGS!!!! Your life is better off that way! Also, it makes you like Tim!!

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14y ago
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14y ago

The most extensively studied effect of cocaine on the central nervous system is the blockage of the dopamine transporter protein. Dopamine transmitter released during neural signaling is normally recycled via the transporter; i.e., the transporter binds the transmitter and pumps it out of the synaptic cleft back into the pre-synaptic neuron, where it is taken up into storage vesicles. Cocaine binds tightly at the dopamine transporter forming a complex that blocks the transporter's function. The dopamine transporter can no longer perform its reuptake function, and thus dopamine accumulates in the extracellular space (synaptic cleft). This results in an enhanced and prolonged post-synaptic effect of dopaminergic signalling at dopamine receptors on the receiving neuron. Prolonged exposure to cocaine, as occurs with habitual use, leads to homeostatic dysregulation of normal (i.e. without cocaine) dopaminergic signaling via downregulation of dopamine receptors and enhanced signal transduction. The decreased dopaminergic signalling after chronic cocaine use may contribute to depressive mood disorders and sensitize this important brain reward circuit to the reinforcing effects of cocaine (e.g. enhanced dopaminergic signalling only when cocaine is self-administered). This sensitization contributes to the intractable nature of addiction and relapse. Dopamine-rich brain regions such as the ventral tegmental area, nucleus accumbens, and prefrontal cortex are frequent targets of cocaine addiction research. Of particular interest is the pathway consisting of dopaminergic neurons originating in the ventral tegmental area that terminate in the nucleus accumbens. This projection may function as a "reward center", in that it seems to show activation is response to drugs of abuse like cocaine in addition to natural rewards like food or sex. While the precise role of dopamine in the subjective experience of reward is highly controversial among neuroscientists, the release of dopamine in the nucleus accumbens is widely considered to be at least partially responsible for cocaine's rewarding effects. This hypothesis is largely based on laboratory data involving rats that are trained to self-administer cocaine. If dopamine antagonists are infused directly into the nucleus accumbens, well-trained rats self-administering cocaine will undergo extinction (i.e. initially increase responding only to stop completely) thereby indicating that cocaine is no longer reinforcing (i.e. rewarding) the drug-seeking behavior. Cocaine also blocks sodium channels, thereby interfering with the propagation of action potentials; thus, like lignocaine and novocaine, it acts as a local anesthetic. Cocaine also causes vasoconstriction, thus reducing bleeding during minor surgical procedures. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra. Recent research points to an important role of circadian mechanisms and clock genes in behavioral actions of cocaine. Because nicotine increases the levels of dopamine in the brain, many cocaine users find that consumption of tobacco products during cocaine use enhances the euphoria. This, however, may have undesirable consequences, such as uncontrollable chain smoking during cocaine use (even users who do not normally smoke cigarettes have been known to chain smoke when using cocaine), in addition to the detrimental health effects and the additional strain on the cardiovascular system caused by tobacco. In addition to irritability, mood disturbances, restlessness, paranoia, and auditory hallucinations, crack can cause several dangerous physical conditions. It can lead to disturbances in heart rhythm and heart attacks, as well as chest pains or even respiratory failure. In addition, strokes, seizures and headaches are common in heavy users. Cocaine can often cause reduced food intake, many chronic users lose their appetite and can experience severe malnourishment and significant weight loss.

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9y ago

There are many things a drug can do to the body, but it seems that the

"stimulant" drugs….drugs like cocaine and amphetamine ("speed")…do more

than their share of bodily harm!

Mainly, cocaine makes you breathe heavier, harder and forces your heart to

pump much faster. Your pupils dilate, your blood pressure goes through the

roof, and your body temperature rises. This kind of over-activity can

cause some serious permanent damage if the drug is taken over a period of

time….it's not terribly uncommon for a frequent user to suffer heart

attacks or respiratory failure, partly because of all of this

wear-and-tear!

Other effects of taking cocaine for a long time include "stimulant

psychosis", a permanent disorder that closely resembles schizophrenia.

Paranoia and tactile hallucinations (hallucinations that you feel…..like

bugs crawling on and/or under your skin). Other problems that come from

cocaine use include irritability, restlessness, anxiety, insomnia,

and--sometimes--seizures.

Health problems from bad circulation and poor nutrition are rather common,

too. The latter one is partly because stimulants--like cocaine--are also

appetite suppressants. Cocaine users don't eat much, so their nutritional

intake really suffers.

Lots of people sniff cocaine, and it's a serious irritant! People who use

cocaine a lot this way eventually wear down their mucous membranes and end

up with serious nasal problems! Smoking it will obviously cause

respiratory disorders, on top of the stimulant effect that I mentioned

before, and injecting any drug is a very common way of transmitting

blood-borne diseases like HIV, and hepatitis.

As you can see, cocaine can do a lot of damage to a person's body…not just

by the drug itself, but by the things you may do while under it's

influence, or the way it is taken into the body. There's more information

on this (and other drugs) at this site check it out!

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15y ago

First and foremost, cocaine affects the brain and central nervous system. By stimulating areas deep in the brain, it initially causes the brain to produce powerful sensations of pleasure. However, interfering with the normal function in these areas produces sensational disfunction and physical addiction usually accompanied by serious long-term psychological disturbances. The cardiovascular system is affected. Cocaine can cause heart attacks and strokes. When in use it increases one's heart rate and sky rocket's one's blood pressure. It also suppresses appetite which can cause malnutriton. Cocaine also has damaging effects on the respiratory system, the gastrointestinal system, and the renal system. The renal system is a serious concern in even moderate cocaine use, since damage to the kidneys is accumulative and usually irreversible.

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14y ago

Cocaine affects the body by, going through your veins and messing with your blood stream. It can cause damage to the brain and blood cells

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15y ago

HELLO IM DAFFY DUCKCAN I HELP YOU ANSWER YOURQUESTION? WHY YES IT DOESAFFECT THOSE AREAS AND HOWDO I KNOW THAT? WELL I AM DAFFY DUCK!REMEMBER KIDSDAFFY DUCK TO THE RESCUE

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12y ago

it can Make your teeth fall out, your bones become weaker, and your skin looks like if it was burned

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13y ago

It affects your penis you get a massove erection thays why ots so addicting...

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13y ago

Yes it does because coke has certain bad acid's and ingredients it contains caffeine And that's bad for you.

Its good for you

never!

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Q: What systems of the body does cocaine affect?
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