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Yes it does. Although people get different effects from it, it gets me angry and annoyed over perfetic things. Along with other side effects; hot sweats, irregular bleeding and sore breasts. Its worth a try as ure protected against pregnancy for 3 months and the symptoms wear off after 12weeks as it is out of your system. If your thinking about getting the implant get the depo shot first as it will have the same effects on you as depo, except you have to have the implant in for at least 6months so you will be stuck with the side effects.

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13y ago
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Q: Does the depo shot make you angry?
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