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it binds to the active sites of the enzyme and does not allow substrate to bind with it

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Q: How TCA stop reaction of alkaline protease?
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TCA cycle is Amphibolic in nature-Why?

In aerobic organisms the TCA is amphibolic pathway, one that both srves in the catabolic and anabolic processes. besides its role in the oxidative catabolism of carbohydrates, fatty acids and amino acids, the cycle provides precursors for many biosynthetic pathways


What compound is generated in the TCA cycle?

1atp, 1fadh2 ,3nadh+h


Why is grinding of the sand and TCA necessary in preparing glycogen?

secret! para bibo! :))


What are the two other names for Krebs cycle?

Citric Acid Cycle TCA Cycle (tricarboxcylic acid cycle).


Can you use chloroacetone in Friedal crafts reaction?

Hi everyone, Recently I read about chloroacetone as a tear gas agent, and decided to make my own, resulting in a mishap that is burning my eyes as of this typing. What I theorized: (Mono)Chloroacetone can be made by bubbling chlorine through a mix of acetone and water with a tiny amount of dilute sulfuric acid. (CH3)CO + Cl2 --> (CH3)(CH2Cl)CO + HCl Unsymmetrical dichloroacetone supposedly can be made the same way with more chlorine, with the advantage that it is comparatively insoluble in water and separates as a dense oily layer and can be sep funneled out, whereas monochloroacetone needs distillation for purification. Since I don't have an effective glassware setup for chlorine bubbling, I decided to go an alternate route, that of pool TCA and acetone with a small amount of HCl as catalyst: TCA powder would be added to acetone with a small amount of HCl. The following ought to occur- (CNOCl)3 + 3HCl --> (HCNO)3 + 3Cl2 3Cl2 + 3(CH3)2CO --> 3(CH3)(CH2Cl)CO + 3HCl and thus the HCl would act as a catalyst. In practice it should be a problem of having 'just enough' HCl to have a SLOW decomposition of TCA to cyanuric acid. Too fast, and it seemed to just bubble out on small trials (with water added to prevent disastrously fast reaction). What I did: It was kind of a disaster, but it could have been worse had it been done indoors. I took 30 grams of acetone and weighed out and powdered 39 grams of TCA, roughly stoichiometric amounts. I added a little sulfuric acid (maybe 0.25 grams) and about a mL of water to the acetone. Then I poured about 1/3 of the TCA into the acetone mix. (Noted that TCA is pretty soluble in acetone, about 30% or so). Nothing seemed to happen. No greenish tinge or anything, no smell (other than acetone, of course). I let it sit about an hour and nothing happened. Eventually I decided I had to speed things up. I took a drop of 10% HCl and put it in the bottom of a test tube and dropped a couple mL of the acetone/TCA liquid (I'd be terrified to pour HCl directly into the ~70 grams of reaction mix!) in the test tube and swirled. A faint green color appeared after a while but nothing else. Deciding that it was not doing anything, I poured the liquid in the test tube back into the reaction vessel (a recycled glass honey jar). I came in and ate dinner with my family. After dinner my mom started complaining that her eyes were burning. I immediately thought of the liquid I had outside, but decided that it was impossible because we were inside and it was outside. Eventually my eyes began to sting a little and I went outside to find the once clear liquid acetone/TCA solution having turned into what appeared to be a grey-white rock. Immediately my eyes, nose and throat began to burn, and though barely able to see I managed to screw the lid on the glass jar. (There ought to be a gas mask smiley). I am guessing that the reaction did nothing for a while and then suddenly decided it wanted to go runaway and spew out a hot cloud of acetone and chloroacetone vapors into my yard, which then somehow managed to wind its way into our house. Poor outdoor animals! Keep in mind that I only added 1/3 of the TCA. I am not sure exactly what the solid is in the sealed jar, as I've left it outside and will check it out tomorrow. The questions for you guys: Essentially I am asking on some good ways to moderate the reaction, so that it doesn't go insane and blow forth poisonous gas clouds at inopportune moments, such as when I am ladeling TCA into the mix. One thing I thought of was having 50% acetone and 50% water, instead of just straight acetone. Would this moderate the reaction? The problem is that I do not have a distillation rig, so separating the water afterwards could not be done, unless I could "salt out" the chloroacetone with CaCl2 or some similar high solubility salt, as was stated on an alternate chloroacetone synthesis I saw on the Net (using different reagents). Another thing I could try is to have the acetone well acidified with HCl and H2SO4, and add the powdered TCA in SMALL quantities over a long period of time. Is this feasible? The one problem I see with it is a labor problem; it would necessitate adding TCA multiple times to a liquid that was continually fuming lacrimatory vapors at me. I am searching for a slow, one-step (in terms of adding chemicals into the flask) reaction. Any ideas on moderating this beast?