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The Sea Lamprey got into the Great Lakes via the St. Lawrence Seaway in the early fifties.

Until then, Lakes Michigan and Superior were famous for their Lake Trout fisheries. The lamprey totally devastated that, and while strides have been made by the Michigan Department or Natural Resources and Environment in controlling the lamprey, the fishery has never completely recovered.

The Zebra Mussel I am well familiar with, but I am not completely clear on it's long-term effect on the fishery - future edits to this question may help.

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