Infectious Diseases

How can UTIs be cured?

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Wiki User
2007-08-13 18:38:13

If the UTI is treated early, the use of antibiotics may be

avoided. Several products are available over the counter. Most

uncomplicated UTIs can be treated with oral antibiotics such as

trimethoprim, cephalosporins, nitrofurantoin, or a fluoroquinolone

(e.g. ciprofloxacin, levofloxacin). Whilst co-trimoxazole was

previously internationally used (and continues to be used in the

U.S.), the additional of the sulphonamide gave little additional

benefit compared to the trimethoprim component alone, but was

responsible for its both high incidence of mild allergic reactions

and rare but serious complications. If the patient has symptoms

consistent with pyelonephritis, intravenous antibiotics may be

indicated. For acute pyelonephritis, use Aminoglycoside plus

Ampicillin (I.V.). Patients with recurrent UTIs may need further

investigation. This may include ultrasound scans of the kidneys and

bladder or intravenous urography (X-rays of the urological system

following intravenous injection of iodinated contrast material). If

there is no response to treatments, interstitial cystitis may be a

possibility. During cystitis, uropathogenic Escherichia coli

(UPEC) subvert innate defenses by invading superficial umbrella

cells and rapidly increasing in numbers to form intracellular

bacterial communities (IBCs). Researchers at Center for Genomic

Sciences, Allegheny Singer Research Institute, and the Department

of Microbiology and Immunology, Drexel University College of

Medicine have shown that biofilms are responsible for chronic

infections and, from a clinical perspective, traditional antibiotic

therapy will never be a successful treatment against biofilm

bacteria. [1] 1.

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