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How can seprate p-nitro acetanilide mixture of para and ortho acetanilide?
Wiki User
∙ 12y ago
The amide group on acetanilide is an ortho/para director, so a simple nitration should work: a mixture of sulfiric acid and nitric acid should be sufficient. Afterward, separation of the ortho and para compounds (by column chromatography, probably) would be necessary.
Wiki User
∙ 14y ago
Wiki User
∙ 12y agoOn the Basic of polarity we can separate them on TLC (Thin Layer chromatography) plate.
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Why para-nitro acetanilide is insoluble in water whereas ortho-nitro acetanilide is soluble in water?
p-nitro phenol has a symmetric structure as compare to o-nitro phenol so it has higher dipole moment or polarity so is more soluble.
Ortho effect on acidity of carboxylic acid?
ortho effect reduces acidity of carboxylic acid. It is due to steric hindrance at ortho position
Is fluorine a pure substance or a mixture?
xylene is a mixture of ortho, meta and para methyl substituted toluene.
Uses of ortho iodo benzoic acid?
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Why methyl attached to benzene is ortho-para director group?
This group attached to benzene ring acts as the ortho-para directing group due to Hyperconjugation.
Why acetanilide brominates in the ortho and para positions and the amount of o-bromoacetanilide?
The polarization of bromine in bromoacetanilide reaction
Why is only 4-bromoacetanilide created mainly from a bromination of acetanilide?
The Acetanilide is a benzene with a acetamido group attached to it. The acetamido group is electron donating and therefore it directs other substituents to the ortho and para positions. The acetamido group is also a very large group and the ortho position is right besides the acetamido group. This creates steric hindrance from bromine from getting to the ortho position and therefore only para-bromoacetanilide or 4-bromoacetanilide is created mainly from a bromination of acetanilide.
Why para-nitro acetanilide is insoluble in water whereas ortho-nitro acetanilide is soluble in water?
p-nitro phenol has a symmetric structure as compare to o-nitro phenol so it has higher dipole moment or polarity so is more soluble.
Why in bromination of acetanilide using bromine in acetic acid give para bromoacetanilide as major product?
The -NHCOR group is less powerfully activating then the -NH2 group. In addition, the degree of steric hindrance is much greater in the case of a -NHCOR group, such as is found in acetanilide. This results in the compound being much more para directing. For an example, see Morrison and Boyd 's text "Organic Chemistry", sixth edition, Page 848.
How can you produce parabromobenzealdehyde from bromobenzene?
When a mixture of carbonmonoxide and HCl is added to Bromobenzene (Gatterman's reaction) a mixture of ortho and para product is obtained which may be separated on the bases of solubilities.
What brand of birth control pills have ortho tricyclen?
Ortho Tricyclen is made by Ortho.
What has the author Fred Thomas Gregorio written?
Fred Thomas Gregorio has written: 'The analysis of mixture of ortho and para dichlorobenzene by the measurement of physical constants'
What chemicals are in ortho evra?
Ortho Evra contain ethinylestradiol and norelgestromin.
What is the difference between Ortho Cyclen and Ortho Tri Cyclen Lo?
Tri-cyclen Lo and Ortho Tri-Cyclen Lo are the same pill.
Where can you find more information about ortho-cylen if all the websites you see are for low or tricyclen?
Hi, Below is information for you relating to ortho cyclen. Ortho Cyclen ethinyl estradiol and norgestimate (ETH in ill ess tra DYE ole and nor jess TI mate) Ortho Cyclen, Ortho Tri-Cyclen, Ortho Tri-Cyclen Lo What is the most important information I should know about Ortho Cyclen?
Ortho effect on acidity of carboxylic acid?
ortho effect reduces acidity of carboxylic acid. It is due to steric hindrance at ortho position
When was Ortho-McNeil Pharmaceutical created?
Ortho-McNeil Pharmaceutical was created in 1993.
