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CREB is a transcription factor whose name is short for cAMP response element-binding protein. It is classically activated by the cAMP intracellular signaling cascade, in which elevated intracellular cAMP levels activate cAMP-dependent protein kinase (PKA). PKA then activates CREB by phosphorylating it on specific serine and threonine admino acid residues, changing the properties of CREB so that it can bind DNA and other proteins to regulate transcription of certain genes.

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Q: How can you increase CREB levels?
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