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How cofactor work?

Updated: 11/1/2022
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13y ago

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Usually there are three kinds of proteins that could bind to an enzyme to enhance its catalytic activity. The prosthetic groups are one that are firmly attched to the enzymes. The best example of a prosthetic group is heme that is bound to hemoglobin.

The next is co factor, that could dissociate itself from the enzyme, like NADH and NADPH.

Cofactor, finally, are metal ions, usually cations, that bind to the metal ions and enhance the activity. they perform certain functions; as to hold the substrates in close proximity. The best example is DNA and RNA polymerase, where the upcoming nucleotide is held in the catalytic cleft of polymerase by Magnesium ions.

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13y ago
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Q: How cofactor work?
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