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Other statistics about Marfan syndrome
- 75% of people with Marfan syndrome have an affected parent.
- Approximately 25% of all cases are due to de novo(spontaneous) genetic mutations. This means they are the first person in their family to be affected.
- Marfan syndrome is an autosomal dominant mutation; this means that, if the mutation is present, the person has the syndrome to at least a mild degree. It can not skip generations. A person with Marfan has a 50% chance of passing it on to their children.
- Estimates indicate that approximately 0.02% of the global population has Marfan syndrome.
- Marfan syndrome is found equally in all ethnicities.
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How common is glaucoma among Marfan syndrome patients?
This condition is much more prevalent in patients with Marfan syndrome than in the general population.
How common is Marfan syndrome among other inheritable disorders?
Marfan syndrome is one of the more common inheritable disorders.
How common is marfan syndrome?
Marfan's syndrome is the most common genetic disorder of connective tissue. It occurs in about every 10,000 to 20,000 individuals.
What are common external signs of Marfan syndrome?
The most common external signs associated with Marfan syndrome include excessively long arms and legs, with the patient's arm span being greater than his or her height.
What did Abraham Lincoln and akhenaten have in common?
Marfan's Syndrome, also known as Froehlich's
Is Marfan Syndrome common in a specific race?
About 1 in 5,000 people have Marfan syndrome, including men and women of all races and ethnic groups. About 3 out of 4 people with Marfan syndrome inherit it, meaning they get the genetic mutation from a parent who has it. But some people with Marfan syndrome are the first in their family to have it; when this happens it is called a spontaneous mutation. There is a 50 percent chance that a person with Marfan syndrome will pass along the genetic mutation each time they have a child.
How often do Marfan syndrome come?
It is found in about every 7,000 births. It is not more common in any particular gender or ethnicity.
Did Abraham Lincoln have any handicaps?
Lincoln did not have any common physical handicaps. There is a conjecture that he suffered from Marfan syndrome. He suffered from periods of despair , but probably not severe enough to classed an clinical depression.
Where can you find information on pectoral concavity?
The medical terminology for the condition is pectus excavatum. It is a common characteristic of people who have Marfan's Syndrome, and their website probably has the most detailed account on all the factors involved.
What population groups tend to get thoracic outlet syndrome?
Thoracic outlet syndrome is most common in women who are 35 to 55 years of age.
How common is restless legs syndrome?
As much as 10% of the population of the United States and Europe may suffer from some degree of restless legs syndrome.
What is the genetic cause of Marfan syndrome?
Marfan syndrome is a disorder of the connective tissue. Connective tissue provides strength and flexibility to structures throughout the body such as bones, ligaments, muscles, the walls of blood vessels, and heart valves. It is caused by a mutation in fibrillin, which decreases fibrillin production and increases TGF-B production. 90-95% of people with Marfan syndrome are able to identify their mutation on FBN1. The other 5-10% may have a mutation on another gene that affects the production of fibrillin which we have not yet discovered. Marfan syndrome affects most organs and tissues, especially the skeleton, lungs, eyes, heart, and the large blood vessel that distributes blood from the heart to the rest of the body (the aorta). The signs and symptoms of Marfan syndrome vary widely in severity, timing of onset, and rate of progression. Affected individuals often are tall (as compared to unaffected family members) and slender, have elongated fingers and toes (arachnodactyly), and have an arm span that exceeds their body height. Other common features include unusually flexible joints, a long and narrow face, a highly arched roof of the mouth, crowded teeth, an abnormal curvature of the spine (scoliosis), and either a sunken chest (pectus excavatum) or a protruding chest (pectus carinatum). About half of all people with Marfan syndrome have vision problems caused by a dislocated lens (ectopia lentis) in one or both eyes, and most have some degree of nearsightedness (myopia). Clouding of the lens (cataract) may occur early on, even in childhood, and increased pressure within the eye (glaucoma) occurs more frequently in people with Marfan syndrome than in those without the condition.
