I don"t know about this health problem. The Spanish Queen died in childbirth giving birth to Prince Miguel ( Michael) this was in l504. Comatose state and child-birth are not, normally the same symptom.
coma from a fever
Queen Isabella died in 1504 from haveing a coma!!
Which Queen Isabella?
Isabella was Queen of Castile and Leon
Queen Isabella became queen in the year of 1474
The brother of Queen Isabella was Alfonso.
Queen Isabella's husband was King Ferdinard of Aragon.
queen Isabella Christopher Columbus asked King Ferdinand & Queen Isabella of Spain for money to try out his idea of traveling west to reach the East. Queen Isabella refused Columbus at first. Later King Ferdinand and Queen Isabella gave Columbus three ships, a crew of about ninety men, and some money. The three ships were the Niña, Pinta, and Santa María.
Queen Isabella
King Ferninand married Queen Isabella
It was king Ferdinand and Queen Isabella :)
Queen Isabella and King Ferdinand financed or sponsored columbus' travels the the "New Woorld".