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SSRIs increase the concentration of serotonin in the gap between the neuron synapses in certain part of the brain. This is the method of action of SSRIs, but WHY does this cause anti-depressant effect, it is still to be found.

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12y ago
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13y ago
The straight answer is that no one knows for sure. The prevailing hypothesis is the neurotransmitter hypothesis.

For example, specific serotonin reuptake inhibitors (SSRIs) work by inhibiting the reuptake of serotonin back into the presymaptic nerve terminal for metabolism and re-synthesis. By allowing more serotonin to remain in the synapse, improved serotnergic functioning may occur. And since Swedish studies have shown very low serum serotonin levels in post-mortem individuals after suicide, it has been inferred that low serotonin levels correspond to depressive disorders (but not definitively proven).

Similarly, serotonin norepinephrine reuptake inhibitors (SNRIs) affect both serotonin and norepinephrine.

Tricyclic agents may be either predominantly serotonergic or noradrenergic.

Monoamine oxidase inhibitors (MAOIs) predominantly affect norepinephrine.
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Q: The drugs called SSRIs relieve depression how?
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