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What is the difference between T cell receptors and MHC molecules?
T cell receptors bind to MHC class 1 molecules. MHC class 1 molecules bind to peptides (self or foreign) and present it to the cell's membrane. The job of a T cell is to decide what is presented on the MHC class 1 cell whether to leave it alone or to activate to destroy it because it is non-self.
How do phagocytes recognize foreign cells or bacteria?
Lymphocytes are part of the human body's innate immune system. Natural killer cells seek out and destroy foreign cells by distinguishing surface molecules of major histocompatibility complex class.
Where are MHC molecules located on a cell?
MHC molecules are located in the short arm of chromosome 6.
What is the role of cytotoxic T cells and describe their mechanism of action?
The role of cytotoxic T cells is to alert Class I MHC molecules to a foreign antigen. This is achieved by the foreign antigen associating with the MHC molecule and being moved out to the cell surface, where the cytotoxic T cell alerts the MHC molecule of the infection.
What cell surface molecule is a major agent in tissue rejection?
Class I and II MHC molecules are what the body uses to recognize it's own cells as "self". If it detects an antigen (anything foreign to the body) the immune system will trigger a response.
Does thymic selection destroy MHC molecules?
The thymus goes through a positive and negative selection for T cells. T cells will respond to MHC class 1, either ignore if self or activate to destroy if foreign.
Does mhc recognize bacteria?
MHC doesn't "recognize" bacteria or anything. It's job is simply take up the broken peptides. These peptides can be originally from a virus, bacteria, or from the cell itself (self). It will take these antigen that it can bind to and bring it to the cells surface. Your adaptive immunity cells (B and T cells) job is to "see" what the MHC has to offer and identify it as self (leave alone) or as foreign (need to destroy).
What is the role of MHC?
MHC is to present on a cell's surface for your T cells and antibodies to determine if it is self or foreign.
Difference between MHC class1 and MHC class2 molecules?
MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.
What is the difference between MHC and HLA?
MHC (major histocompatability complex) is the term for the molecules in all vertebrates. HLA (human leukocyte antigen) is the specific term for that class of molecules in humans.
When MHC will be expressed?
MHC I and MHC II are always expressed. The antigen it presents on a cells surface can be foreign or it can be self. It is the T cell that determines whether what the MHC is displaying is self or not. Remember antigen can be protein, lipid, sugars, etc.
Class II MHC molecules are found only on which of the following?
Presented by APCs as MHC-exogenous peptide complex
