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The first thing to do when your dog is on her period is to make sure that you wipe her down so she will be clean alittle and make sure that she has doggie pads.

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Q: How do take care of the female dog during period time and is it safe to keep them as pet?
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How do you clean up after a female dog's period?

It would be best to keep her confined to an easily cleaned area that has no carpet, upholstered furniture or beds. Then just soap and water should work to clean up. You can also buy pads for her to wear during "her time".