You can't open the safe door. Go over the ceiling.
There isn't one you have to use the cherry bomb to blast it open
You use it to open some door in the far back of the island.
You can't open the door. Go over the top instead : climb up and come in through the ceiling of the room.
You can't open the door, but you can go over it.
Use the Cherry Bomb from the tree at the bottom right, which can blast open the cage. (for full solution, see related question)
There is no key. However, there is a large hole in the ceiling of the vault.
you walk out the door
There isn't a locker in spy island, but there is in Big Nate island.
you dont. go on the shelves beside it and climb. at the top there's an entrance to the vault.
You go up on the roof of the B.A.D. fort and use the fingerprint glass to open the door.
If you mean the eye doctor on spy island, his office is on the bottom. He lets you go into the top.
There is no crowbar on spy island. To get through the bars on the window, you must have a laser pen, and to open the cage in the greenhouse, you must push a cherry bomb in front of the door by using the pop-up flowers.