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I have a disease known as Restless Leg Syndrome. It causes my right leg to jump apparently spontaneously every 20 seconds unless I have taken enough medicine to quell the cyclic events. The medicine I take is called pramipexole. Before bedtime I take about three milligrams of pramipexole in pill form by mouth. As I begin to awaken after sleeping, my right leg jumps autonomously every twenty seconds until I get up and am fully awake. At that time, the jumping apparently stops. I can also get some relief from this disease by walking about until my legs are tired, requiring about 20 to minutes of steady walking. If I don't either walk or take a sufficient amount of pramipexole, the leg-jumping occurs as I begin to fall asleep, and the movement is so violent that it awakens me, after which the jumping is again delayed until I am again almost asleep, when it recurs. This pattern of apparently spontaneous muscle spasm is so regular that it keeps the sufferer (i.e., me) awake for hours until I am so sleep deprived that I can fall asleep in spite of the action of my leg.

So here is the question: What is the activity in the brain that occurs every 20 seconds in periods of quasi-wakefulness or near sleep? What brain activity during sleep occurs with such perfect regularity? Is this a demonstration of biorhythm in the form of a disease?

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