You have to get the flies away from Ratman to defeat him. Climb up past the three rats on the right side to reach the final red wheel. Click it to dump sludge on Ratman. Now the flies attack you, but you can Dodge them long enough to jump to the large center pipe, and over to where Ratman is.
u spin the weel and a bunch of gunk comes out
Ratman is hiding in the sewer under City Park, with his pet rats and stinging flies.
She flies away. Fly after her (not too close to begin with) and dodge the green energy balls she throws. After a couple of minutes, you can get close enough to knock her down. (see related question)
You can't always. Try to jump near Sir Rebral. Eventually he will hit himself and get mad. When he starts pulling up chunks of the ground, slide the rock over from the restrooms so that it flies up and hits him.
On Super Power Island, Betty Jetty is atop of the skyscraper in the Downtown area. The building is cordoned off with yellow warning tape. To chase her, you will need to fly. Defeat the other five super-villains (without the flying power), and you will receive your flying power. (The phone in the phone booth will ring.) Go to the skyscraper and chase her when she flies away.
Once you enter the control room, climb past the rats at right to reach the final red control wheel. This will dump sludge on Ratman and the flies will attack you. Dodge them until you can jump to the large center pipe, and then to Ratman.
In the sewers on Super Power Island, Ratman is guarded by rats and stinging flies. When you find him, go right and jump the rats to reach the final red wheel at upper right. This dumps sludge on Ratman and the flies. Now they will chase and sting you. Go far right, then run back left and quickly climb the BIG pipe in the middle, from which you can jump to Ratman. The flies are always right behind you.
When you climb up to the right and turn the red wheel, it dumps sludge on Ratman and scares away the rats. However, the stinging flies attack you. Dodge them long enough to reach the large pipe in the center, from which you can jump over to Ratman and put the cuffs on.
Once you have dumped sludge on Ratman, his rats run away. But the stinging flies will attack you. Avoid them long enough to jump to the large pipe at the center, then over to Ratman. Cuff him.
Unlike the rats and flies, the roaches are just a crawly distraction in the subway before you fight with Speeding Spike. You can't affect them at all.
You can't. You have to go around them. They move in regular patterns and you can jump past them in a couple of different ways, to reach the red control wheel at the upper right. When you do, the flies will leave Ratman and attack you, so dodge them and climb the big pipe at the center to jump over to Ratman.
Shuve it up your as*