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A mole of water at STP occupies approximately 18 cc. Take an eye dropper and add drops of water to a graduated cylinder until it equals 18cc. (We'll assume that your eyedropper technique is consistent enough that each drop is equal...otherwise you need more accurate equipment...you could also do this by weight). From this you can calculate that your drop is .X of a mole (For example if 18cc is 1800 drops then X is 0.01. From there you can calculate how many molecules of water are in your drop by multiplying Avogadro's number by your calculated X...and multiplying by 3 since their are 3 atoms (2H and 1O) per molecule of water to get the number of atoms in your drop.

If accuracy is required you'd best hit the lab for equipment...as the chances of a truly accurate answer anywhere else are slim and none. But you could do this for fun with a 1cc TB syringe. You do the math.

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