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Depends on whether this is 145 East 49th Street or 145 West 49th Street.

If it's 145 East 49th: 145 East 49th is between Lexington and 3rd Avenues. Walk half a block west to Lexington, and 2 blocks north to East 53rd Street. Take the Downtown E train (of the A-C-E, the blue line) from Lexington Avenue-53rd Street to 34th Street-Penn Station.

If it's 145 West 49th: 145 West 49th is between 7th and 6th Avenues, only 3/4 of a mile from Penn Station. So you can just walk there: half a block west to 7th Avenue, and then 15 blocks south to 34th Street. Penn Station is at 33rd to 34th Street, between 8th and 7th Avenues.

If you want to take the subway, then walk half a block west to 7th Avenue, and take the Downtown N-R-Q (the yellow line), 1 stop, from 49th Street (at 7th Avenue) to 42nd Street-Times Square. Transfer at Times Square to the Downtown 1-2-3 (the red line), 1 stop, from 42nd Street-Times Square to 34th Street-Penn Station.

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