About 670 miles.
425 miles
The city that is halfway between Columbus, OH, and Fort Lauderdale, FL, is Mooresville, NC. When traveling such a long distance, stopping overnight at the halfway point is a good idea.
about a day and 3 hours in car
Anywhere from two days to two weeks.
6 hours 20 mins driving..... 379 miles
The shortest driving time is 10 hours and 43 minutes.
Greenville, OH
Why don't you just mapquest It
A typical flight between Cincinnati, OH and Greenville, SC would have a flying time of about 38 minutes.
If you take I-95 there are no tolls in NC or Virginia. As of a couple years ago, there were none in SC either.
Columbus is southwest of Cleveland.