0
Want this question answered?
Be notified when an answer is posted
Add your answer:
Earn +20 pts
Can a frameshift mutation be a silnt mutation?
A frameshift mutation completely changes the genetic code from the point of the mutation, so the protein made as a result of the mutation would have the incorrect structure and would not function as it should.
Which type of mutation will probably have a larger effect A point mutation or a frameshift?
Both types of mutation have the potential to cause a large effect.In general, a frameshift mutation is more likely to cause a large effect. This is because it shifts the 'reading frame' - so that all of the subsequent codons (groupings of 3 bases that are read to determine which amino acid will be added) will be changed.A point mutation is when a single base is replaced. This can either result in the same amino acid being added to the protein being synthesised (a silent mutation), a different amino acid being added (a missense mutation) or in a STOP codon (a nonsense mutation).If a point mutation causes a premature STOP codon - this is quite likely to have a large effect on the protein.
What is the difference between a nonsense mutation and a frame shift mutation?
A point mutation is where a single letter is the only thing changed in the DNA sequence. Lets say your phone number (or DNA code) was 483-1839 and you mistakely told someone that your phone number was 483-1835. that one digit is enough to make that person dial the wrong number (or cause a mutation in DNA.) For example suppose your DNA sequence was ACT GCT, a point mutation would just be a change in one of those bases (or letters), so it could end up something like : ACT ACT.EX: GTA CTG CAA-----> (point mutation) -----> GTA GTG CAAA frameshift mutation is generally much more serious and will cause a change all the way down a DNA sequence, making each codon (or every group of three bases) a different sequence, not just in one point or base like a point mutation, that would only slightly change the sequence of a single codon. A frameshift mutation happens not when a DNA base is simply changed, but when a whole base is added or deleted from the sequence of DNA. For example lets suppose your DNA sequence is GTA CCT AGG. In a frameshift mutation a whole base would be added somewhere in that sequence, making it look something like this: GTAT CCT AGG. Since it is impossible though to have 4 bases in a codon, your body would automatically shift every letter down one, even to the next codon in the sequence, to make room for this new base. In the end the final product would look something like this: GTA TCC TAG (with the left over G being the first base in the next codon, and so on).EX: CAG TTC CTG GAA -----> (frameshift muation) -----> CAG TTA CCT GGAAs you can see the frameshift mutation would leave the mutated DNA vastly more different from its parent DNA (that it was replicated from), then a point mutation would, though in both cases the DNA would still be different/mutated. This is because the codons would be more considerbaly changed with the frameshift (where now the sequence in every codon in different), rather than in a point mutation (where only one of the codons would be different).Hope this helps all you HS Bio 1 people like myself out there, or anyone else studying this subject.-- K.J.S
Why do a frame shift mutation usually cause more defects during protein synthesis that a point mutation?
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly. Here is an example of one sentence with words of only three letters: The big red pig ate the red rag. Each word will make one amino acid and the words make a sentence that makes sense. Mutations that replaces one base for another will result in this: The beg red peg ate the red rag. This mutation can be read OK. But another type might make the sentence totally readable: The big res dpi gat eth ere dra.
What do you call a change in the genetic code?
gene- coding or gene manipulationor if youre looking for the answer from novelstars ;;; MUTATION :D
Which mutation results in a single missing letter in the genetic code?
frameshift mutation: deletion
Can a frameshift mutation be a silnt mutation?
A frameshift mutation completely changes the genetic code from the point of the mutation, so the protein made as a result of the mutation would have the incorrect structure and would not function as it should.
How would a protein be changed if a mutation caused a base to be added?
A mutation in which an extra nitrogen base is added is called a frameshift mutation. The rest of the sequence after the mutation will code for different amino acids, which will result in the alteration of the protein. Frameshift mutations cause severe genetic disorders.
Why frameshift mutations have greater effect than point mutations?
A substitution mutation means that one base was copied incorrectly within a string of DNA. Since it takes three DNA bases to code for a single amino acid, only one amino acid is affected. A frameshift mutation, on the other hand, refers to an insertion or deletion of any number of DNA bases NOT divisible by three. This mutation throws off EVERY other amino acid after it and tends to be devastating. For example, if you had this sequence: actgactga, you would get three amino acids: act, gac, and tga. If you had a substitution error, it might yield cctgactga. In this case, only the first acid would be different. In the case of an insertion (one type of frameshift mutation), you might get: acttgactga. As you can see, a t-base has been added towards the beginning. in this case, you would get the amino acid sequence: act, tga, ctg. EVERY amino acid following the mutation is different from what it should be.
Which is more harmful frameshift mutation or point mutation?
point mutations include substitutions insertions and deletions of single nucleotides in DNA. insertions and deletions have a greater effect on proteins than do substitutions because insertions and deletions affect every amino acid that is specified by the nucleotides that follow the point mutation. in contrast a substitution affects a single amino acid. a change in more than one amino acid is more than likely to alter the ability of the protein to function normally than is a change in a single amino acid
Which type of mutation will probably have a larger effect A point mutation or a frameshift?
Both types of mutation have the potential to cause a large effect.In general, a frameshift mutation is more likely to cause a large effect. This is because it shifts the 'reading frame' - so that all of the subsequent codons (groupings of 3 bases that are read to determine which amino acid will be added) will be changed.A point mutation is when a single base is replaced. This can either result in the same amino acid being added to the protein being synthesised (a silent mutation), a different amino acid being added (a missense mutation) or in a STOP codon (a nonsense mutation).If a point mutation causes a premature STOP codon - this is quite likely to have a large effect on the protein.
What might the result of a mutation of DNA in which a triplet code such as CAC now says CTC?
In this situation, a substitution is occurring. If only one triplet codon is changed, only one amino acid is changed, and a very minor mutation occurs.
What is the difference between a nonsense mutation and a frame shift mutation?
A point mutation is where a single letter is the only thing changed in the DNA sequence. Lets say your phone number (or DNA code) was 483-1839 and you mistakely told someone that your phone number was 483-1835. that one digit is enough to make that person dial the wrong number (or cause a mutation in DNA.) For example suppose your DNA sequence was ACT GCT, a point mutation would just be a change in one of those bases (or letters), so it could end up something like : ACT ACT.EX: GTA CTG CAA-----> (point mutation) -----> GTA GTG CAAA frameshift mutation is generally much more serious and will cause a change all the way down a DNA sequence, making each codon (or every group of three bases) a different sequence, not just in one point or base like a point mutation, that would only slightly change the sequence of a single codon. A frameshift mutation happens not when a DNA base is simply changed, but when a whole base is added or deleted from the sequence of DNA. For example lets suppose your DNA sequence is GTA CCT AGG. In a frameshift mutation a whole base would be added somewhere in that sequence, making it look something like this: GTAT CCT AGG. Since it is impossible though to have 4 bases in a codon, your body would automatically shift every letter down one, even to the next codon in the sequence, to make room for this new base. In the end the final product would look something like this: GTA TCC TAG (with the left over G being the first base in the next codon, and so on).EX: CAG TTC CTG GAA -----> (frameshift muation) -----> CAG TTA CCT GGAAs you can see the frameshift mutation would leave the mutated DNA vastly more different from its parent DNA (that it was replicated from), then a point mutation would, though in both cases the DNA would still be different/mutated. This is because the codons would be more considerbaly changed with the frameshift (where now the sequence in every codon in different), rather than in a point mutation (where only one of the codons would be different).Hope this helps all you HS Bio 1 people like myself out there, or anyone else studying this subject.-- K.J.S
Why do a frame shift mutation usually cause more defects during protein synthesis that a point mutation?
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly. Here is an example of one sentence with words of only three letters: The big red pig ate the red rag. Each word will make one amino acid and the words make a sentence that makes sense. Mutations that replaces one base for another will result in this: The beg red peg ate the red rag. This mutation can be read OK. But another type might make the sentence totally readable: The big res dpi gat eth ere dra.
What is a Missence mutation?
A mutation that causes the code for the wrong amino acid (apexvs.com)
What is the type of mutation that causes hemophilia?
There is no single type of mutation that causes Hemophilia A. It is not the type of mutation but rather the location of the mutation within the genetic code.
What type of mutation is the most significant effect on protein synthesis?
Mutations change the order in which the organic bases are in your DNA. These bases code for proteins, and if they change, so the code changes. A change in the code can mean a different protein is made or that proteins are not made at all. The way it could stop proteins from being made is that the change could create a Stop Codon, which stops mRNA from being translated (which would then be transcribed into proteins). If it forms a Start Codon, then the wrong section of DNA could be translated and the wrong proteins be synthesised. There is not always a change in to proteins synthesised, as for each amino acid in a protein there is more than one code. A mutation could change the code for a protein into a different code, but for the same protein. In such a case there would be no change.
