In a frameshift mutation, the stop codon may be altered or shifted, potentially leading to a change in the reading frame of the genetic code. This can result in the formation of a different protein or a longer protein than intended, affecting the normal functioning of the cell.
The mutation would result in a change in the amino acid sequence during protein synthesis. In this case, the amino acid encoded by the codon CAC is histidine, while the codon CTC encodes for leucine. This mutation can lead to changes in the protein's structure and function, potentially altering its properties.
A substitution mutation means that one base was copied incorrectly within a string of DNA. Since it takes three DNA bases to code for a single amino acid, only one amino acid is affected. A frameshift mutation, on the other hand, refers to an insertion or deletion of any number of DNA bases NOT divisible by three. This mutation throws off EVERY other amino acid after it and tends to be devastating. For example, if you had this sequence: actgactga, you would get three amino acids: act, gac, and tga. If you had a substitution error, it might yield cctgactga. In this case, only the first acid would be different. In the case of an insertion (one type of frameshift mutation), you might get: acttgactga. As you can see, a t-base has been added towards the beginning. in this case, you would get the amino acid sequence: act, tga, ctg. EVERY amino acid following the mutation is different from what it should be.
If one base in a codon was changed, this would be a point mutation. This may not cause any change in the structure of the protein, or it could be severely damaging. Since most amino acids have more than one codon, it's possible that the mutation would result in one of the other codons for that amino acid. In that case, there would be no change in the sequence of amino acids, and no change in the structure or function of the protein. A point mutation might also result in a codon that codes for a totally different amino acid, which can cause a genetic disorder. One example of a genetic disorder caused by a point mutation is sickle cell anemia. It's also possible that the point mutation could cause the codon to code for a stop signal. Please read the article in the related links for more information.
If an extra nitrogenous base is deleted from the mRNA code, it can disrupt the reading frame, leading to a frameshift mutation. This can change the amino acid sequence of the resulting protein, potentially altering its structure and function. The protein may not be properly synthesized or may not function correctly, affecting cellular processes.
A mutation involving a change in the base sequence of DNA can disrupt the coding information stored within the gene, potentially leading to changes in the protein produced. These mutations can have various effects, ranging from no impact to causing genetic disorders or diseases, depending on the specific location and nature of the mutation.
The mutation would result in a change in the amino acid sequence during protein synthesis. In this case, the amino acid encoded by the codon CAC is histidine, while the codon CTC encodes for leucine. This mutation can lead to changes in the protein's structure and function, potentially altering its properties.
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly. Here is an example of one sentence with words of only three letters: The big red pig ate the red rag. Each word will make one amino acid and the words make a sentence that makes sense. Mutations that replaces one base for another will result in this: The beg red peg ate the red rag. This mutation can be read OK. But another type might make the sentence totally readable: The big res dpi gat eth ere dra.
If one base in a codon was changed, this would be a point mutation. This may not cause any change in the structure of the protein, or it could be severely damaging. Since most amino acids have more than one codon, it's possible that the mutation would result in one of the other codons for that amino acid. In that case, there would be no change in the sequence of amino acids, and no change in the structure or function of the protein. A point mutation might also result in a codon that codes for a totally different amino acid, which can cause a genetic disorder. One example of a genetic disorder caused by a point mutation is sickle cell anemia. It's also possible that the point mutation could cause the codon to code for a stop signal. Please read the article in the related links for more information.
A substitution mutation means that one base was copied incorrectly within a string of DNA. Since it takes three DNA bases to code for a single amino acid, only one amino acid is affected. A frameshift mutation, on the other hand, refers to an insertion or deletion of any number of DNA bases NOT divisible by three. This mutation throws off EVERY other amino acid after it and tends to be devastating. For example, if you had this sequence: actgactga, you would get three amino acids: act, gac, and tga. If you had a substitution error, it might yield cctgactga. In this case, only the first acid would be different. In the case of an insertion (one type of frameshift mutation), you might get: acttgactga. As you can see, a t-base has been added towards the beginning. in this case, you would get the amino acid sequence: act, tga, ctg. EVERY amino acid following the mutation is different from what it should be.
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The person might end up getting cancer.
The person might end up getting cancer.
If one base in a codon was changed, this would be a point mutation. This may not cause any change in the structure of the protein, or it could be severely damaging. Since most amino acids have more than one codon, it's possible that the mutation would result in one of the other codons for that amino acid. In that case, there would be no change in the sequence of amino acids, and no change in the structure or function of the protein. A point mutation might also result in a codon that codes for a totally different amino acid, which can cause a genetic disorder. One example of a genetic disorder caused by a point mutation is sickle cell anemia. It's also possible that the point mutation could cause the codon to code for a stop signal. Please read the article in the related links for more information.
Changing a base pair on a human chromosome (or any organism's chromosome) can range from no effect to catastrophic. The changing of a base pair -- a mutation -- can either result in a nonsense mutation, a missense mutation, or a silent mutation.A nonsense mutation changes a codon upstream of the normal stop codon into a stop codon, resulting in a truncated protein. Such proteins are non-functional and usually result in a non-viable offspring although some can survive (with serious genetic disorders).A missense mutation is just like a nonsense mutation, except the codon isn't changed into a stop codon and the protein does not terminate early. The only difference between the normal protein and the affected protein is that the affected protein will have one amino acid along the polypeptide chain that is different. The affects of such a change can change the shape of the protein entirely, seen with sickle-cell anemia.A silent mutation has no effect on the protein produced. There are only 20 amino acids, but 43 variations of four bases arranged three at a time (in other words, there are 64 different codons possible). Accordingly, more than one codon can code for the same amino acid. For example, both UAU and UAC code for the amino acid tyrosine. Imagine a point mutation replaced the U in UAU with a C making it UAC. Either way, the amino acid that will be used will be tyrosine, in no way changing the structure of the protein. For that reason, these mutations are "silent" or having no effect.
If an extra nitrogenous base is deleted from the mRNA code, it can disrupt the reading frame, leading to a frameshift mutation. This can change the amino acid sequence of the resulting protein, potentially altering its structure and function. The protein may not be properly synthesized or may not function correctly, affecting cellular processes.