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What does markedly mean?
You could use the word "substantially" instead. Say you saw someone after a lot of years, you could say they had changed markedly. Or if someone did something good or bad that affected someone else a lot you would say that it had affected them markedly. ...
How does the pronunciation of markedly differ from the pronunciation of marked?
In markedly the ed is prounounced mark- ed-ly. Marked is pronounced as though there is only a d on the end 'markd' ...