You could use the word "substantially" instead. Say you saw someone after a lot of years, you could say they had changed markedly. Or if someone did something good or bad that affected someone else a lot you would say that it had affected them markedly.
Her performance markedly improved after she switched coaches and began training with Brian Orser.
In markedly the ed is prounounced mark- ed-ly. Marked is pronounced as though there is only a d on the end 'markd'
The word freaky means a thing or occurrence that is markedly unusual or irregular. Some other words that mean the same as freaky are unusual, irregular, queer, and abnormal.
markedly
No, it is not an adverb. The word marked is a past tense verb (and past participle) and can be used as an adjective. The related adverb is "markedly" but means to a substantial or noticeable degree (e.g. markedly different standards).
freak means: a person or animal that is markedly unusual or deformed
isoniazid
The recordings of these last two interviews are markedly inferior.
Adipose tissue
greatly, very much, significantly, remarkably, substantially, markedly, noticeably, appreciably
Severe, definitely, clearly, obviously, plainly, patently, decidedly, markedly, noticeably
Less than 4 is a normal perfusion study; 4-8 is mildly abnormal 9-13 is Moderately abnormal 13 is Markedly Abnormal