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End plate potential is the change in potential from neurotransmitters. It can be excitatory or inhibitory. If the action potential wants to continue, it will be excitatory and vice versa. It can be additive, if more action potentials are fired it will increase the end plate potential.

An action potential is an all or none response. It will either proceed or it will not proceed depending on the terms of the threshold. It cannot be additive, because there is an absolute refractory period where no additional action potentials can be fired.

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a postsynaptic potential is isolated at a synapse, and is graded (diminishing in strength with distance), whereas an action potential is the result of an accumulation and summing of the electrotonic conduction of many postsynaptic potentials, and is an all or none impulse, retaining its strength regardless of distance traveled.

The movement of a postsynaptic potential is called electrotonic conduction.

A postsynaptic potential occurs at just one site on a neuron, from a limited number of sodium ions input to the neuron by the action of neurotransmitters at that synapse, whereas an action potential results from a summing of some number of electrotonic impulses derived from many postsynaptic potentials, which cause a cascade of successive sodium ion inputs along an axon.

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Q: How does the end plate potential differ from a EPSP on a post synaptic cell?
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Is end plate current the same as end plate potential?

No, end plate current of excitatory post-synaptic current(EPSC) represents the sum of the currents through thousands of AChRs in the postsynaptic membrane. The end-plate potential or Excitatory post-synaptic potential(EPSP) is the local depolarisation at the post-synaptic membrane which eventually results in an action potential at the postsynaptic membrane of the neuromuscular junction. EPSP is much slower than the EPSC because of the time necessary to charge and discharge the capacitance of the muscle membrane. Hope this helps, there is a lot more detail in the notes we were given which I'll be happy to share if you need it.


What determines if an action potential is initiated in the postsynaptic neuron?

Every time neurotransmitter is released from the presynaptic neuron it generates an excitatory post synaptic potential(EPSP) in the postsynaptic neuron. When the EPSP is greater than the threshold for excitation an action potential is generated.


What is the difference between action potentials and synaptic potentials?

A synaptic potential exists at the INPUT of a neuron (dendrite), and an action potential occurs at the OUTPUT of a neuron (axon). (from OldGuy)(from Ilantoren:) A synaptic potential is the result of many excitatory post synaptic potentials (epsp) each one caused by the synaptic vesicles released by the pre-synaptic terminus. If there are enough of these epsp then the responses will summate and depolarize the post-synaptic membrane at the axon hillock enough to fire an action potential.


What are epsp?

EPSP is an abbreviation for excitatory postsynaptic potential. This is a graded depolarization of a postynaptic membrane responding to neurotransmitter stimulation.


What type of membrane potential is generated at the synapse on the postsynaptic membrane?

It can be an excitatory postsynaptic potential (EPSP) or an inhibitory postsynaptic potential (IPSP), depending on the synapse. The EPSP depolarizes the membrane, while the IPSP hyperpolarizes it.


What determines whether a neuron has an action potential?

epsp's & IPSP's


What is the difference between EPSP and an IPSP?

An EPSP is an excitatory postsynaptic potential, which represent input coming from excitatory cells, whereas an inhibitory postsynaptic potential represents input driven by inhibitory presynaptic cells.


Which is greater - The extent of membrane polarization at threshold potential or that of the resting membrane potential?

A cell is more depolarized at it's threshold potential than it is at it's resting potential. This is important because a nervous system where a random excitatory post synaptic potential (epsp) would trigger the next neuron would lead to an overly excitable nervous system (btw, this is why caffeine makes you jittery).


What is synaptic facilitation?

an action will happen cause of axo-axonal syanapse,which can facilitate the nerve impulse transmitting from presynaptic membrane to post synaptic membrane. In the axo-axonal synapse one axon is secreting serotonin which can influence to close some of K+ channels in the other neuron to maintain a prolonged action potential by slowing down the repolarization. as long as action potential is there it can stimulate the presynaptic membrane to release neurotransmitters towards postsyanptic membrane so prolonged action potential will help to stimulate more the Post synaptic membrane and give a strong impulse this is called presynaptic facilitation


What will occur when an excitatory postsynaptic potential EPSP is being generated on the dendritic membrane?

A single type of channel will open, permitting simultaneous flow of sodium and potassium.


What is presynaptic inhibition?

Inhibition of a stimulatory neuron before it synapses, by inhibiting Ca2+ entry and blocking downstream processes, preventing neurotransmitter release, and therefore preventing the neuron generating and EPSP post-synaptically.


When a second EPSP arrives at a single synapse before the effect of the first have disappeared what occurs?

temporary summation