Every time neurotransmitter is released from the presynaptic neuron it generates an excitatory post synaptic potential(EPSP) in the postsynaptic neuron. When the EPSP is greater than the threshold for excitation an action potential is generated.
action potential
Hyperpolarization of the membrane. This inhibits action potential generation.
epsp's & IPSP's
The sodium influx necessary for depolarization will occur more slowly making the action potential difficult to generate.
Correct. The action potential is initiated at a specific point on the cell membrane called the axon hillock, and it then travels down the axon in one direction. Once initiated, it spreads along the entire length of the axon and can be transmitted to other neurons or muscle cells.
An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential.
action potential
Hyperpolarization of the membrane. This inhibits action potential generation.
End plate potential is the change in potential from neurotransmitters. It can be excitatory or inhibitory. If the action potential wants to continue, it will be excitatory and vice versa. It can be additive, if more action potentials are fired it will increase the end plate potential. An action potential is an all or none response. It will either proceed or it will not proceed depending on the terms of the threshold. It cannot be additive, because there is an absolute refractory period where no additional action potentials can be fired.
refractory period is the interval between action potential , the absolute refractory period is the period in which second action potential can not be initiated but in relative refractory period the second action potential can be initiated by the more strong stimulus.
epsp's & IPSP's
An excitatory postsynaptic potential, a type of graded potential, occurs because of the influx of Na+ through chemically gated channels in the receptive region, or postsynaptic membrane, of a neuron. Graded potentials are generated by chemically gated channels, whereas action potentials are produced by voltage-gated channels.
A synapse and an action potential have a flip-flopping cause and effect relationship, in that an action potential in a presynaptic neuron initiates a release of neurotransmitters across a synapse, which can then subsequently potentially trigger an action potential in the axon of the postsynaptic neuron, which would then cause release of neurotransmitters across a following synapse.
Presynaptic neurons release the neurotransmitter in response to an action potential. Postsynaptic neurons receive the neurotransmitter (and can however become presynaptic to the next nerve cell, if the neurotransmitter has stimulated the cell enough).
After the action potential reaches the presynaptic terminal, voltage-gated calcium channels open, leading to an influx of calcium ions. This triggers the release of neurotransmitters into the synaptic cleft. These neurotransmitters then bind to receptors on the postsynaptic membrane, leading to depolarization and the generation of a new action potential in the postsynaptic neuron.
The sodium influx necessary for depolarization will occur more slowly making the action potential difficult to generate.
This the relative refractory period.