Noradrenaline has an amine group with a positive charge as well as two OH groups attached to its benzene ring. The amine group can form an ionic bond with the COOH group with aspartic acid residues in the receptor. Meanwhile, the OH groups can form hydrogen bonds with the OH groups of the serine residues in the receptor. These bonds will lead to noradrenaline binding with the beta receptor.
Cholinergic
dissolved odorants bind to the receptors in the cilium membranes.
There are at lest 3 types of beta receptors and they are found in different organs. Beta-1 (β1) receptors are found in the heart, eye, and kidneys while beta (β2) receptors are found in the lungs, gastrointestinal tract, liver, uterus, blood vessels, and skeletal muscle. The third type, beta (β3) receptors are found in fat cells.
receptors proteins
adrenergic receptor
Cholinergic
Neurotransmitters to the synapse and the neurotransmitters bind with the receptors releasing the second messengers.
The neurotransmitter for sympathetic nervous system is norepinephrine (or also called noradrenaline) that acts on adrenergic receptors of the effector organ (alpha 1, beta 1, beta 2 receptors). The adrenergic receptors are G-protein coupled.
dissolved odorants bind to the receptors in the cilium membranes.
This is done through several mechanisms: - Stimulating noradrenaline to be released - Mimicking noradrenaline's action on the receptors -Preventing noradrenaline to be broken down and reuptaken
Acetylcholine.
There are at lest 3 types of beta receptors and they are found in different organs. Beta-1 (β1) receptors are found in the heart, eye, and kidneys while beta (β2) receptors are found in the lungs, gastrointestinal tract, liver, uterus, blood vessels, and skeletal muscle. The third type, beta (β3) receptors are found in fat cells.
beta receptors
receptors proteins
When beta receptors are stimulated, it decreases the heart rate to treat for low blood pressure.
If you stop taking beta blockers abruptly after prolonged use it can cause rebound hypertension and arrhythmias. This is because the drug was blocking beta receptors in your body lowering your blood pressure. Your body has been increasing the number of receptors in your body because of this. If you stop you now have even more receptors for epinephrine to bind to. This will cause your blood pressure to increase drastically. For this reason you should taper the dose over 10 to 14 days.
Clonidine acts on alpha-2 receptors - I have never read that it has activity on mu receptors.