415 miles taking this route:
419 miles
Key West Daytona Beach Florida Keys Any of these will be great destinations for your spring break.
100miles
220 miles taking this route:Take Florida's TURNPIKE (toll) SOUTH, from Boynton Beach, to U.S. 1 SOUTH to KEY WEST at END Florida's TURNPIKE in Homestead.Take U.S. 1 SOUTH to Key West.
419 miles
It is 321.95 miles according to MapQuest.
419 miles
Greyhound
The halfway point between New Smyrna Beach and Key West would be somewhere in West Palm Beach. The exact town I do not know but this is your midpoint.
About 233 miles
It would take about 3 and a half hours to drive by car from Miami Beach, Florida to Key West, Florida. There is approximately 160 miles between the two locations.
1hour