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The driving distance between Lexington, KY and St. Louis, MO is approximately 340 miles. The driving time would be approximately 5 hours 45 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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13y ago
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12y ago

414.9 miles and it will take 6 hours and 42 minutes by car

5 days 7 hours if u walk

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15y ago

260.11 miles

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Q: How far is Louisville KY from St. Louis MI?
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