The shortest driving distance is 311 miles.
5 hours
it is about 50 miles from fort Myers airport to Marco island
104 miles
about 140 miles
130 miles
153 miles
It is 295 miles according to Google Maps.
about 45 minutes, but its an easy drive
295-337 mi. It all depends on what route you take.
about 33 miles
It is about 2 1/2 hours from Fort Myers to Clearwater/St.Petersburg Airport, so depening on where you are in Tampa, and where you want to be in Fort Myers, give yourself about 3 hour., It is 126.00 miles according to MapQuest.
About a 30 minute drive on I-75