Almost due south from Denver, there are 3 different routes you can take from Santa Fe, NM. Stay on I-25N and it is just 395 miles. Take US-160E and I-25N and it is 360 miles. Go all the way on US-285N and it is 358 miles.
santa fe
It is 392.96 mikes according to MapQuest.
It is 393 miles.
Denver CO to Santa Fe NM is 285 miles in a straight line.
About 400 miles.
distance from denver to santa fe is about 400 miles
It is 392 miles via Interstate 25 according to Google Maps.
Both are higher them Denver with Santa Fe at 7,260 feet and Albuquerque at 5,312 feet above sea level.
Well it's about 394.89 miles.
Urban Lights
It is 392.96 miles via I-25.
6 hours