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How germline mutation occur?

Updated: 12/12/2022
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13y ago

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Everyone acquires some changes to their DNA during the course of their lives. These changes occur in a number of ways. Sometimes there are simple copying errors that are introduced when DNA replicates itself. (Every time a cell divides, all of its DNA is duplicated so that the each of the two resulting cells have a full set of DNA.) Other changes are introduced as a result of DNA damage through environmental agents including sunlight, cigarette smoke, and radiation. Our cells have built in mechanisms that catch and repair most of the changes that occur during DNA replication or from environmental damage. As we age, however, our DNA repair does not work as effectively and we accumulate changes in our DNA.

Some of these changes occur in cells of the body - such as in skin cells as a result of sun exposure - but are not passed on to children. But other errors can occur in the DNA of cells that produce the eggs and sperm. These are called germline mutations and can be passed from parent to child. If a child inherits a germline mutation from their parents, every cell in their body will have this error in their DNA. Germline mutations are what cause diseases to run in families, and are responsible for the kind of hereditary diseases covered by Genetic Health.

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Q: How germline mutation occur?
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Related questions

Can mutation heritable?

Mutations are able to be inherited if they occur in your mother or father's sex cells. This is known as a germline mutation.


Is Cystic Fibrosis a Germline mutation or an enviromental Mutation?

yes


What is somatic mutations?

A mutation in a non-germline cell (germline cells are sperm, egg, etc.).


What is a mutation that affects the gametes of an organism?

A mutation that affects the gametes of an organism is called


What can predict whether a mutation in a human skin cell can be passed to its offspring?

A mutation in a human skin cannot be passed on to an offspring, since it is only a somatic mutation which is acquired. The mutation that can be passed on to an offspring is called a germline mutation, which happens in the egg and sperm.


Are mutations in somatic cells heritable?

Nothing in somatic cells is inheritable unless it shows up in the gametes as well. As such, if a somatic cell experiences a mutation, it can only affect that cell and any cell it creates.


What happens if mutations occur in somatic cells of an organism?

A somatic mutation is one that occurs AFTER offspring have been conceived. This means that the mutations are not passed on to the f2 generation of offspring. An example we find in humans is cancer.


Which mutation cannot occur in a tRNA encoding gene?

nonsense mutation


When a child is born chromosomal mutation when did the mutation occur?

During meiosis


When a child is born with a chromosomal mutation when did mutation occur?

during meiosis


What are the types of mutations that can occur?

nonsense mutation, missense mutation, frameshift muation, deletion or addition mutation


If an enzyme is absent during polypeptide production a mutation can occur?

This is a true statement. If an enzyme that is involved in DNA replication is not there, then a mutation can occur.