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Aspirin is metabolised by tissue and blood esterases occurs, hydrolysing aspirin to acetic acid and salicylate. Salicylate is distributed throughout most body tissues and fluids, including synovial fluid and cerebrospinal fluid, and is 50-90% bound to plasma proteins.

You can find heaps in the book I am reading. Pharmocology for Health Professionals by Byrant and Knights, 3rd Edition. p299.

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Q: How is aspirin absorbed and distributed throughout the body?
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