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To have lupus a patient must have four out of eleven abnormalities from a list established by the American Rheumatism Association. These abnormalities are:

1. Malar rash

2. Discoid rash

3. Photosensitivity

4. Mucosal ulcers

5. Serositis

6. Arthritis

7. Renal disorders

8. Neurological disorder

9. Haematological disorder

10. Immunologic disorder

11. Anti-Nuclear Antibody The American College of Rheumatology established these 11 criteria as a means of determining whether or not a patient qualifies to enter lupus clinical trials. In the process of diagnosing lupus, these are helpful but not absolute, some criteria carrying more weight than others. For example, a kidney biopsy that confirms lupus nephritis determines a diagnosis of lupus whether or not any of the other 11 criteria are present. A skin biopsy that confirms cutaneous lupus is all that is needed to make that diagnosis as well. Lupus is diagnosed based on these steps and information: # Medical history # Symptoms # Wide variety of lab tests # After other disorders have been ruled out It should be noted that 10 million Americans have a positive Antinuclear antibody titer (ANA) but only 1.5 million have lupus. Of that 1.5 million with lupus, 5% will have a negative ANA titer. This, according to Daniel Wallace, MD in The Lupus Book.

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15y ago
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14y ago
How Is Lupus Diagnosed?There is no single test to diagnose lupus. It may take months or years for a doctor to diagnose lupus. Your doctor may use many tools to make a diagnosis:
  • Medical history
  • Complete exam
  • Blood tests
  • Skin biopsy (looking at skin samples under a microscope
  • Kidney biopsy (looking at tissue from your kidney under a microscope
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14y ago
What Are the Symptoms of Lupus?Symptoms of lupus vary, but some of the most common symptoms of lupus are:
  • Pain or swelling in joints
  • Muscle pain
  • Fever with no known cause
  • Red rashes, most often on the face
  • Chest pain when taking a deep breath
  • Hair loss
  • Pale or purple fingers or toes
  • Sensitivity to the sun
  • Swelling in legs or around eyes
  • Mouth ulcers
  • Swollen glands
  • Feeling very tired.

Less common symptoms include:

  • Anemia (a decrease in red blood cells)
  • Headaches
  • Dizzy spells
  • Feeling sad
  • Confusion
  • Seizures.

Symptoms may come and go. The times when a person is having symptoms are called flares, which can range from mild to severe. New symptoms may appear at any time.

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13y ago

Lupus is difficult to diagnosis. Rheumatologists are the specialists who diagnose and treat lupus. A diagnosis is based on symptoms, history, a variety of medical tests, and after other disorders have been ruled out. There is no definitive biomarker (lab test) to diagnose lupus. Lupus is four times more prevalent than multiple sclerosis.

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10y ago

There is no definitive test for lupus.

A diagnosis of lupus is based on

  1. Symptoms
  2. History
  3. Variety of medical tests
  4. Process of elimination

Rheumatologists are the specialists trained in the often tricky diagnosis and treatment of lupus. You can find one on the American College of Rheumatology site.

Common tests used in the process of diagnosing lupus include ANA (anti nuclear antibody), anti DSS DNA (anti double stranded DNA), anti Smith, ESR (sedimentation rate), complement, CBC (complete blood count) with differential, and CMP (comphrehensive metabolic panel). Urinalysis, creatine clearance and BUN (blood urea nitrogen) may also be included if lupus nephritis is suspected.

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11y ago

There is no definitive test for lupus. A diagnosis of lupus is based on medical history, symptoms, a variety of tests and process of elimination. Tests commonly used in the diagnositic process include antinuclear antibody (ANA), anti double stranded DNA, sed rate, CBC with differential, CMP (metabolic panel), anti Smith, anti Ro and anti La. There are others but these are among the most common.

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9y ago

There is no definitive test for Lupus. Lupus is difficult to positively diagnose, and is often based on a pattern of symptoms.

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15y ago

There is a blood test that looks for anti-ANA that, along with physical symptoms, confirms the diagnosis.

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Q: How is lupus diagnosed?
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