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Mesopotamia refers to area land between Tigris and Euphrates rivers is Iraq, Syria and part of Turkey. While fertile crescent refers to apart of the same land, although extending roughly as a crescent shape from the Nile delta to the Persian sea. More specifically the fertile crescent is referring to historical terms, as birth of civilization, and referring to fertile volcanic soils and as result of the rivers historically. Where as Mesopotamia is referring more geographically to the location.

They might be used synonymously depending on the context. However they have etymological differences, that should not be confused.

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