From the end of the Sanibel Causeway to Blind Pass, Sanibel Island stretches roughly 10.5 miles long.
21 hours 13 min. 1329.38 miles
one hour 10 minutes
Google Maps estimates the driving time as 48 hours.
Wilmington to Sanibel is 11 h 29 min (775.2 mi) via I-95 S and I-75 S
The Keys are 120 miles long. Sanibel Island to Key West is 311 miles.
About 16 hours
That is a fairly short drive depending on where in Milwaukee you live. Worst case is about an hour.
If you were to drive from Austin to Milwaukee it would take about 19 hours and 2 minutes. That is assuming that you are drving to Milwaukee.
According to mapquest it takes 22hrs and 34mins to drive from Milwaukee Wisconsin to Naple's Florida.
The driving distance between Lexington, KY and Sanibel Island, FL is approximately 975 miles. The driving time would be approximately 16 hours 15 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
Check Mapquest.com