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Several weeks to (depending on duration/dose) months and in extreme cases a year. People have to remember their state of mind before beginning the SSRI. Often people think they should go back to 'normal' when they were not stable before beginning the medication.. so at best they will return to that state. (Sometimes people will return to a normalized state.. which is fantastic. Though it would be prudent to keep in mind that continueing on an AD might be the best option).

I know this isn't the answer you would like to hear, but it is highly varied.

If , for example, Lexapro was used for 2 months,.. It shouldn't take but a few weeks to return to a normalized chemical state. However if used for 2-3 years.. I would venture to guess it could take up to 6 months.. Those who have used it for 5-6.. or more years could be in quite an ordeal for 6months-12months before being 100% pre-AD.

It is not ruled out that certain SSRI's can cause permenant changes in the brain.. however neural plasticity is a very real thing, and the brain can and does adapt and 'heal' itself if given time. Which is often sped up by proper nutrition, excercise, and cognitive therapy. If all combined the recovery can be substantially shortened. Never under-estimate these simply but effective strategies.

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15y ago
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13y ago

Generally two weeks for any effect, and up to six weeks for maximal effect. Note that all individuals are highly variable in their response to drugs (especially drugs of this type) so results will vary.

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15y ago

In my case, heart rate dropped from high 100s to 70 in just 4 hours after taking the first pill. Other symptoms wore off within 30 hours or so.

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Q: How long does it take to feel better after going off of Lexapro?
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