Metoprolol is metabolized differently by different people and so can have a half-life of between 3 and 7 hours. The half-life is the amount of time it takes for the drug level to drop in half. Doctors consider a medication to effectively be gone from the system after 5 half lives.
If your question refers to drug testing, that would depend on the starting level and sensitivity of the test.
If you are asking when its effects will wear off, that will depend on the drug level your pills achieve at their peak and what level controls your symptoms.
Also, there is an extended release pill out that will put significant amounts into your system over 24 hours.
The half-life of Metoprolol is between 3 to 7 hours / so, in 2 days, it will be gone.
The excretion half-life of metoprolol- both immediate and extended release- is anywhere from 3 to 7 hours.
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