How long of a drive is it from Independence mo to Nashville TN?

Answer 1

464 miles

However, driving-wise it is 550 miles taking this route:

1. Take I-70 EAST (towards St. Louis), from Independence, to I-64 EAST to LOUISVILLE, via I-270 NORTH (EXIT 232A off I-70 to get onto I-270 NORTH) & I-255 SOUTH to bypass ST. LOUIS, MO (EXIT 7 off I-270 in Illinois to get onto I-255 SOUTH ; EXIT 20 off I-255 to get onto I-64 EAST to LOUISVILLE).
2. Take I-64 EAST to I-57 SOUTH to MEMPHIS.
3. Continue on I-57 SOUTH to I-24 EAST to Nashville at EXIT 44.
4. Take I-24 EAST to Nasvhille.