Google Maps estimates the drivng time as 34 hours.
as long as it takes
It takes about 5 hours to drive from Orlando, Florida to Islamorada, Florida. The trip is about 325 miles long. It will take longer if there is heavy traffic in the summer months.
4 and 1/2 hours
It is 85.2 miles according to Google Maps.
About 1.25 hours according to MapQuest.
About 10 hours to drive it.
1 hour 18 mins