I can't say from Manchester but I have driven to Luxembourg from Calais and with lunch/toilet breaks at the 81mph speed limit on the French motorway it takes approx 8 hours.
Manchester and Liverpool are only 35 miles (55 km) apart, much too close to fly by scheduled flights. You would be best to drive or take a bus or train.
It takes about 5 hours to drive from central Manchester to Dover. The crossing takes 45-mins, but you need to check-in 1-hour early, so in total, 7-hours. Roughly.
The total distance is 186 miles. The journey would take about 3 hours and 20 minutes.
It would take about 1 hr 45 mins to drive from Penrith, Cumbria to central Manchester.
The 42-miles from central Chester to Manchester airport should take about 45-minutes. During rush hour, this would take considerably longer due to congestion.
Manchunian ?
Considering we are talking about Manchester, England this flight would take 22 hours.
It would take approximately 14 hours to drive the 883 miles from New York, New York, to Manchester, Tennessee.
There are no ferries between Manchester and Glasgow. Drive or take a train.
Leeds, but if you measure it by metropolitan area, it would be Manchester.
165 miles About 3 hours
140 mph