280 mi - about 4 hours 35 mins.
The shortest driving time is 14 hours and 28 minutes.
Google Maps estimates the driving time as 10 hours and 37 minutes.
About sis hours of driving time.
Atlanta is a city and relatively compact but Mississippi is a state. Drive times "to Mississippi" depend on where in Mississippi you are going. Driving from Atlanta to roughly the center of the state of Mississippi, along Interstate 20 would take you about 5.5 hours - and you would still have an hour to go before you got to Jackson, Mississippi.
About 169 miles if you use the Natchez Trace Parkway, but the downside is the speed limit is only 50 mph.
4 and 1/2 hours
Mississippi is a big place. (So is Atlanta, but we'll use a point downtown, near the junction of I-75 and I-20, as the final destination in all cases.) From Gulfport: 400 miles, 7 hours From Natchez: 495 miles, 9 hours From Meridian: 290 miles, 5 hours From Hernando: 375 miles, 7-1/2 hours From Tupelo: 285 miles, 5:50 hours
About 13 hours of driving.
11 hours to Tupelo; 4 or 5 more to Biloxi.
About 8 hours of driving time.
The driving time is about four hours. Or, if you are an aggressive driver trying to get back to Alabama, Mississippi, or Louisiana, the drive from Charlotte to downtown Atlanta is 3.15 to 3.5 hours. :) Average speed 75-85 mph. :)