Approximately 400 miles
Several places are located on the Mississippi River between Memphis, Tennessee, and New Orleans, Louisiana. They include Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Greenville, and Helena.
The distance between Memphis, Tennessee and New Orleans, Louisiana is 395 miles. The estimated driver time is 5 hours and 42 minutes.
390 miles taking I-10 WEST to I-55 NORTH (off EXIT 210), and then taking I-55 NORTH to Memphis, TN.
Minneapolis, Minnesota. St. Louis, Missouri Memphis, Tennessee New Orleans, Louisiana* (Between August 2005 and August 2009, the city of Baton Rouge had a higher city population than New Orleans proper. But the N.O. metro area has more than 1 million residents compared to about 750,000 for Baton Rouge.)
In the shortest route the two largest would be Memphis and Nashville.
About 350 miles from Memphis to Shreveport. Much farther from Knoxville to New Orleans.
The halfway point between Memphis, Tennessee and Louisville, Kentucky is Pegram, Tennessee.
Miles between Franklinton, La. and New Orleans, La.
Nashville, Tennessee
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Memphis
It is 210 miles between Jackson, Mississippi and Memphis, Tennessee via Interstate 55 according to Google Maps.